Evidence of direct interactions between the CC-chemokines CCL3, CCL4 and CCL5 and Leishmania promastigotes.
نویسندگان
چکیده
Parasites of the genus Leishmania are very successful paraites, possessing multiple host evasive machineries and unique olecules that aid in their survival. It is presumed that a freshly noculated parasite needs to survive in the hostile extracelluar environment for several hours before it is internalized by a acrophage [1,2]. How the parasite survives within this extraellular environment and find their way to a macrophage are atters of great interest and enigma to clinicians and biologists like. Chemotactic molecules secreted by the parasite, that are to his day uncharacterized, can home certain host cells and probbly play a major role in the process of inviting host cells to the ite of infection [3]. Host derived chemotactic molecules, espeially chemokines also play an important role in the homing of ells to the site of infection [4]. What is not clear is whether hese host derived chemotactic factors can also be sensed and tilized by the parasites. Chemokines are proteins that act by binding to certain transembrane G-protein coupled receptors. Chemokines are speific for the receptors they bind to although a degree of degenracy exists [5]. Thus, the chemokines CCL3, CCL4 and CCL5 formerly designated MIP1 , MIP1 and RANTES) bind to the eceptors CCR5 and CCR1, but not to any of the other 50 or so eceptors reported [5]. CCL2, although produced from a similar ource and perform a similar function, binds to its cognate recep-
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ورودعنوان ژورنال:
- Molecular and biochemical parasitology
دوره 150 2 شماره
صفحات -
تاریخ انتشار 2006